Laughter decreases stress hormones and increases immune cells and infection-fighting antibodies, thus improving your resistance to disease. Laughter triggers the release of endorphins, the body's natural feel-good chemicals. Endorphins promote an overall sense of well-being and can even temporarily relieve pain. ~Laughter is the next medicine There's nothing like deep breaths after. laughing that hard. Nothing in the world like a sore stomach for the right reasons.